Comment on“Microvascular changes after conbercept therapy in central retinal vein occlusion analyzed by optical coherence tomography angiography”

摘要

Dear Editor,We enjoy reading the retrospectively study by Deng et al[1]which investigated microvascular changes in eyes with macular edema resulting from central retinal vein occlusion(CRVO)before and after intravitreal conbercept(Lumintin;Chengdu Kanghong Biotech Co,Ltd.,China)injection and evaluated correlations between these changes,best-corrected visual acuity(BCVA),and retinal thickness.The authors concluded that optical coherence tomography angiography(OCTA)enables the non-invasive,layer-specific and quantitative assessment of microvasacular changes,and can be used to obtain quantitative data and more detailed information regarding the vascular network of the superficial capillary plexus(SCP)and deep retinal capillary plexus(DCP),outer retina(photoreceptor),and choriocapillaris(choroid)in eyes with CRVO.We would like to address several issues,which make interpretation of these results challenging.There was a selection bias attributable to inclusion in the study and pooled analysis of patients with 2 forms of CRVOs(ischemic and nonischemic occlusions)having definitely different pathogenesis,clinical features,prognoses,and management.Likewise,2 completely different etiologic subgroups of patients have been encompassed and lumped together,namely,patients older than 50y who usually have common systemic conditions such as hypertension,diabetes,and patients younger than 50y,in whom other mechanisms.