机译：AIM:To investigate the expression of matrix metallopr-oteinase-2(MMP-2) and matrix metalloproteinase-9(MMP-9) in retinoblastoma(Rb),and their relationships with tumor development stage.METHODS:Immunohistochemical technique was used to detect the expression of MMP-2 and MMP-9 in 41 cases of paraffin embedded Rb samples.Quantitative analysis of the expression of MMP-2 and MMP-9 was assessed by HMIAS-2000 Color Pathologic Analysis System.The differences of the expression of MMP-2 and MMP-9 in each clinical and pathological stage were analyzed statistically.RESULTS:In all the 41 Rb specimens,MMP-2 and MMP-9 expression was found in tumor cells.The expression of MMP-2 and MMP-9 was significantly higher in tumors with optic nerve invasion than in tumors without optic nerve invasion(P <0.05);the expression of MMP-2 and MMP-9 was significantly higher in tumors of extra-ocular stage than in tumors of glaucomatous stage or intra-ocular stage(P < 0.05).CONCLUSION:MMP-2 and MMP-9 exist in retinoblastoma cells.The level of MMP-2 and MMP-9 is related to optic nerve invasion and clinical stage of Rb,which suggests the expression of MMP-2 and MMP-9 could be connected to the invasion and development of tumor cells.Further research is needed for deeper understanding of the biological behavior and better evaluation of the prognosis of Rb.
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