乳腺癌X线征象与p53、Ki-67表达相关性的研究进展

摘要

乳腺癌是女性最常见的恶性肿瘤之一,其发生、发展过程中大多伴随基因异常表达.p53、Ki-67基因表达情况是指导临床内分泌治疗及判断预后的常用生物学指标.癌基因表达从不同角度反映了乳腺癌的恶性生物学行为,并引起组织病理学改变,进而形成多种影像学表现.因此,乳腺癌X线表现可在一定程度上反映p53、Ki-67的表达情况.乳腺X线检查因诊断病变的准确率高、操作简单、价格低廉,是临床筛查及诊断乳腺癌的首选方法,并成为预测乳腺癌病人p53、Ki-67表达情况的无创手段.在无条件做免疫组化的情况下,乳腺X线征象与基因表达的相关性对乳腺癌术前评估及非手术治疗发挥重要作用,具有潜在的临床应用价值.%Breast cancer is one of the most common female malignant tumors.The occurrence and development of breast cancer are often accompanied by abnormal gene expression.It has been well accepted that p53,Ki-67 are the commonly used biological indicators for clinical endocrine therapy and prognosis prediction.The oncogene expression reflects the malignant biological behavior of breast cancer from different perspectives.Those aggressive behaviors cause a variety of changes in histopathology and thus in imaging.Therefore,the imaging features of breast cancer may indirectly demonstrate the status of p53,Ki-67.Until now,because of its facility,low cost and high accuracy,mammography is still the preferred method in breast cancer screening and diagnosis.The relationship of mammographic appearances and gene expression in patients with breast cancer has potential clinical value in preoperative evaluation and planning of non-surgical treatment for those who are not able to perform immunohistochemistry.