Objective To investigate the relationship between atherosclerosis diseases and the risk factors,such as homocysteine (HCY) , and to analyze the differences of the risk factors in different atherosclerosis diseases. Methods The serum levels of low-density lipoprotein(LDL) ,lipoprotein(a)[Lp(a)] , uric acid(UA) , HCY and high sensitive-C reaction protein(HS-CRP) were parallel detected in 120 cases of patients with acute cerebral infarction(ACI group) ,103 cases with coronary heart disease(CHD group) , 43 cases with peripheral artery disease(PAD group) and 50 healthy controls(control group). The contrastive analysis and multivari-ate analysis were conducted. Results ACI,CHD and PAD group all showed significant differences from the control group,including the serum levels of LDL, Lp(a) ,UA, HCY and HS-CRP( He = 76. 789,13. 982,21. 788,28. 550, X2 = 16. 041,P<0. 05). Multivari-ate analysis indicated that each risk factor had a different degree of correlation with different atherosclerosis diseases. Conclusion The serum levels of LDL, Lp(a) , UA, HCY and HS-CRP could be closely related with atherosclerosis diseases. Each risk factor might have a different degree of correlation with different atherosclerosis diseases. Early detection of LDL, Lp(a) , UA, HCY and HS-CRP could have positive significance for preventing and curing atherosclerosis diseases.%目的 探讨同型半胱氨酸(HCY)等危险因子在动脉粥样硬化疾病中的表达差异及与该疾病的相关性.方法 对120例脑梗死患者、103例冠心病患者、43例动脉闭塞症患者以及50例健康对照人群同时测定血清低密度脂蛋白(LDL)、脂蛋白a[Lp(a)]、尿酸(UA)、HCY、超敏C反应蛋白(HS-CRP),并作对比分析及多元回归分析.结果 脑梗死、冠心病以及动脉闭塞组的血清HCY、LDL、Lp(a)、UA、HS-CRP表达水平与健康对照组差异有统计学意义(Hc=76.789、13.982、21.788、28.550,χ2=16.041,P<0.05).多元回归分析显示,不同危险因子与不同动脉粥样硬化疾病的相关性不同.结论 HCY、LDL、Lp(a)、UA、HS-CRP水平增高与动脉粥样硬化疾病密切相关,并且各危险因子与各疾病相关程度不同,及早检测各危险因子,对动脉粥样硬化疾病的预防、治疗有着非常积极的意义.
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