肿瘤标志物联合检测在肺癌诊断及鉴别诊断中的应用价值

摘要

目的：探讨血清神经元特异性烯醇化酶（NSE）、细胞角蛋白 CK19片段（Cyfra21-1）等6种肿瘤标志物在该院肺癌的诊断及鉴别诊断中的应用价值。方法采用电化学发光免疫法检测140例肺癌、57例肺良性疾病患者和45例健康体检者的血清 NSE、Cyfra21-1、糖类抗原19-9（CA19-9）、糖类抗原12-5（CA12-5）、血清鳞状细胞癌抗原（SCC-Ag）、癌胚抗原（CEA），观察这6种肿瘤标志物在肺癌的诊断及肺癌与肺良性疾病鉴别诊断中的价值。结果肺癌组 CA12-5、CA19-9、CEA 水平均显著高于肺良性疾病组及健康体检组（P ＜0．05）；6种肿瘤标志物联合检测的灵敏度和准确度分别为95．2％、89．7％，均优于单项检测。结论肿瘤标志物需联合检测可提高肺癌诊断的灵敏度和准确度，有助于肺癌早期的鉴别诊断。%Objective To investigate the application value of 6 kinds of tumor markers serum neuron-specific enolase(NSE),cy-tokeratin 19 fragment(Cyfra21-1),carbohydrate antigen 19-9(CA19-9),carbohydrate antigen 12-5(CA12-5),squamous cell carcino-ma antigen(SCC-Ag),carcino embryonic antigen(CEA)in the diagnosis and differential diagnosis of lung cancer.Methods Serum NSE,Cyfra21-1,CA19-9,CA12-5,SCC-Ag and CEA levels were detected in 140 cases of lung cancer,57 cases of benign lung disea-ses and 45 individuals with healthy physical examination as control group by electrochemiluminescence immunoassay.The values of these 6 kinds of tumor marker in the diagnosis and the differential diagnosis of lung cancer were observed.Results The levels of CA12-5,CA19-9 and CEA in the lung cancer group were significantly higher than those in the benign lung diseases group and the healthy physical examination group(P <0.05 ),the sensitivity and accuracy in the combined detection of the six kinds of tumor marker in diagnosing lung cancer were 95.2% and 89.7% respectively,which was superior to those in single index detection.Con-clusion The tumor makers need to be jointly detected,which can increase the sensitivity and accuracy for diagnosing lung cancer and conduces to the differential diagnosis of early lung cancer.