不同年龄段儿童维生素D水平变化及其与血红蛋白的相关性

摘要

目的：调查0～12岁儿童的维生素D水平，探讨儿童维生素D水平与血红蛋白（HGB）水平的相关性。方法选取2013年郴州市第一人民医院儿童保健科门诊体检的0～12岁儿童共计3254例，采集儿童基本发育指标并取清晨空腹血，检测25‐羟维生素D水平及 HGB等相关临床指标。对维生素D水平的总体分布和不同年龄段的分布情况进行初步统计分析；并对各年龄段的维生素D水平与 HGB的相关性进行探讨。结果现阶段郴州地区78．9％的儿童维生素D水平处于正常水平；儿童外周血的维生素D水平随着年龄的增长呈明显下降趋势（ r＝－0．510，P＜0．05）。研究还发现0～＜2、4～＜6、7～＜10岁3个年龄段儿童HGB水平在维生素D正常组要明显高于低含量组，儿童体内维生素D水平与 HGB存在正相关（P＜0．05）。进一步分析发现，0～＜2、4～＜6岁年龄段的维生素D水平与 HGB水平呈正相关（P＜0．05），而7～＜10岁年龄段两者无相关性。结论现阶段郴州地区儿童维生素D营养状况总体良好，儿童维生素D水平随年龄的增长呈明显下降趋势，符合儿童生长发育特点；在不同年龄段，儿童维生素D与HGB水平存在正相关性，维生素D缺乏可能影响儿童 HGB生成，导致儿童贫血的发生。%Objective To investigate the vitamin D level among children aged 0-12 years old and its correlation with hemoglo‐bin (HGB) level .Methods 3 254 children aged 0-12 years old in the child healthcare department of our hospital during 2013 were selected .The basic development indicators were collected and the fasting blood was extracted for detecting the related clinical indi‐cators of 25‐hydroxyl vitamin D level ,HGB ,etc .The situation of vitamin D overall distribution and distribution among different age stages were performed the preliminary statistical analysis ;the correlation between vitamin D level among different age stages with HGB was investigated .Results The vitamin D level among 78 .9% of children in Chenzhou city was in the normal level .The pe‐ripheral blood vitamin D level showed the significantly decreasing trend with the age increase (r= -0 .510 ,P<0 .05) .Our study found that the HGB levels during 3 age stages of 0- <2 ,4- <6 and 7- <10 years old in the normal vitamin D level group were obviously higher than that in the low vitamin D level group .The vitamin D level in children was positively correlated with HGB(lev‐el P<0 .05) .The further research found that the vitamin D level in the age stages of 0- <2 ,4- <6 years old was positively corre‐lated with the HGB level(P<0 .05) ,while no correlation between them was found in the age stage of 7- <10 years old .Conclusion The vitamin D nutritional status in children of Chenzhou city is good in general now .The vitamin D level in children appears a ob‐viously downward trend with the age increase ,which conformed to the children′s growth and development characteristics ;in differ‐ent age stages ,the positive correlation exists between children′s vitamin D and HGB levels ,the vitamin D deficiency may affect chil‐dren′s hemoglobin generation ,thus could lead to anemia occurrence in children .