LncRNAs表达水平与膀胱癌患者预后关系的Meta分析

摘要

Objective To systematically uncover the correlation between the expression level of long chain non coding RNA(LncRNA)and the prognosis of bladder cancer patients Methods Databases including PubMed,Web of Science,and China National Knowledge Infrastructure(CNKI)were searched for relevant literatures about the the correlation between the expression level of LncRNAs and the prognosis of bladder cancer.After data were extracted,a Meta-analysis was performed using STATA12.0 software.Results A to-tal of 7 eligible studies including 722 cases were acquired from the databases that met the inclusion criteria. The Meta analysis showed that high expression of LncRNAs is associated with a shorter life period in patients with bladder cancer(HR=2.23,95% CI:1.64 -3.04,P<0.01).Conclusion The high expression of LncR-NAs has a certain relationship with the poor prognosis of bladder cancer and is expected to be a potential bio-logical target for predicting the prognosis of bladder cancer.%目的 探讨长链非编码 RNA(LncRN A)表达水平与膀胱癌患者预后的相关性.方法 检索PubMed,Web of Science和China National Knowledge Infrastructure(CNKI)数据库中关于LncRNAs表达水平与膀胱癌预后相关性的文献,提取相关数据后采用STATA12.0软件进行Meta分析.结果 纳入7篇文献,共计722例患者.Meta分析结果显示:LncRNAs高表达与膀胱癌患者总生存期较低存在相关性(H R=2.23,95% C I:1.64~3.04,P<0.01).结论 LncRN As高表达与膀胱癌的不良预后有一定的关系,有望成为潜在的判断膀胱癌预后的生物靶标.