Noninvasive diagnosis of nonalcoholic steatohepatitis: Emerging approaches

摘要

Nonalcoholic steatohepatitis(NASH),a severe type of nonalcoholic fatty liver disease(NAFLD),progresses toward liver fibrosis/cirrhosis,liver failure,and furthermore,hepatocellular carcinoma(HCC)[1].The pathological manifestations are hepatocyte steatosis( >5%),lobular inflammation,and ballooning degeneration,with or without fibrogenesis[2].NAFLD/NASH results from sedentary life style,western diet,and obesity.We have witnessed the conversion of spectrum of chronic liver diseases from viral hepatitis as the leading cause to NAFLD/NASH worldwide[3].Diagnosis of NASH is therefore of great importance for the clinical management,evaluation,and follow-up.