Risk factors for the occurrence of insulinoma:a case-control study

摘要

BACKGROUND: The etiology of insulinoma is poorly understood. Few studies investigated the possible roles of environmental factors  and  lifestyle  in  the  pathogenesis  of  insulinoma.  The aim  of  this  study  is  to  identify  risk  factors  associated  with occurrence of insulinoma in the Chinese population. METHODS:  This study consisted of 196 patients with insulinoma and 233 controls. Demographic information of the patients and controls and risk factors of the disease were analyzed. Univariate and  unconditional  multivariable  logistic  regression  analyses were made to estimate odds ratios (ORs) and possible risk factors. RESULTS: Approximately 68.88% (135/196) of the patients were from rural areas in contrast to 10.30% (24/233) of the controls (P<0.0001). This difference was confirmed by the multivariate analysis  (OR=4.950;  95%  CI:  2.928-8.370).  Family  history  of pancreatic endocrine tumor (OR=16.754; 95% CI: 2.125-132.057) and  other  cancers  (OR=2.360;  95%  CI:  1.052-5.291)  was  also related to a high-risk population of insulinoma. CONCLUSION: Rural  residents  or  people  who  have  a  family history of pancreatic endocrine tumor and other cancers are a high-risk population of insulinoma.