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首页> 外文期刊>国际肝胆胰疾病杂志（英文版） >A correlation of computed tomography perfusion and histopathology in tumor edges of hepatocellular carcinoma
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A correlation of computed tomography perfusion and histopathology in tumor edges of hepatocellular carcinoma

机译：肝细胞癌边缘的计算机断层扫描灌注与组织病理学的关系

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摘要

BACKGROUND: The peripheral morphologic characteristics of hepatocellular carcinoma (HCC) relfect tumor growth patterns. Computed tomography (CT) perfusion is a new method to analyze hemodynamic changes in tissues. We assessed the relationship between CT perfusion and histopathologic ifndings in the periphery of HCC lesions. METHODS: Non-contrast CT, enhanced dual-phase CT, and CT perfusion were performed on 77 subjects (47 patients and 30 controls). Based on the imaging ifndings of enhanced dual-phase CT, the tumor edges were classiifed into three types: type I (sharp); type II (blurry); and type III (mixed). The CT perfusion  parameters  included  hepatic  blood  lfow,  hepatic arterial fraction, hepatic arterial perfusion, and hepatic portal perfusion. The tissue sections from resected specimens were subjected  to  routine  hematoxylin  and  eosin  staining  and immunohistochemical  staining  for  CD34.  The  correlations between microvessel density (MVD) and the CT perfusion parameters were analyzed using Pearson's product-moment correlation coefifcient. Changes in the perfusion parameters in tumor edges of different tumor types were evaluated. RESULTS: Type I (sharp): the pathologic ifndings showed ifbrous connective tissue capsules in the tumor edges, and an MVD ≤ 30/mm2. Type II (blurry): the histology showed that the edges were clear with no capsules and an MVD >30/mm2. Type III (mixed): the pathology was similar to that of types I and II, and an MVD >30/mm2. Hepatic blood lfow, hepatic arterial fraction, hepatic arterial perfusion, and hepatic portal perfusion were signiifcantly increased in the tumor edges of HCC patients compared to those of the controls (P<0.05). The correlation between CT perfusion parameters and MVD was higher in blurry tumor edges of type II than in those of types I or III. CONCLUSION: CT perfusion imaging of tumor edges may be helpful in revealing histopathological features, and indirectly relfect angiogenic changes of HCCs.
机译：背景：肝细胞癌（HCC）影响肿瘤生长的模式的外周形态学特征。计算机断层扫描（CT）灌注是分析组织中血流动力学变化的一种新方法。我们评估了HCC病变周围CT灌注与组织病理学发现之间的关系。 方法：对77例患者（47例患者和30例对照）进行非对比CT，增强双相CT和CT灌注。基于增强型双相CT的成像发现，将肿瘤边缘分类为三种类型：I型（锋利）;类型II（模糊）;和“ III”型（混合）。 “ CT”灌注参数包括“肝血流量”，“肝动脉分数”，“肝动脉灌注”和“肝门静脉灌注”。将来自切除标本的组织切片应用于常规的苏木精和曙红染色以及CD34的免疫组织化学染色。利用皮尔逊的乘积矩相关系数分析了微血管密度（MVD）和CT灌注参数之间的相关性。评估了不同肿瘤类型的肿瘤边缘灌注参数的变化。 结果：类型I（锋利）：在病理边缘显示的病理学发现为纤维状结缔组织胶囊，MVD≤30 / mm2。 II型（糊状）：组织学研究表明，边缘清晰，无胶囊，MVD> 30 / mm2。 III型（混合）：病理学与I型和II型，MVD型> 30 / mm2相似。肝癌患者的肿瘤边缘显着提高了肝血流量，肝动脉灌注分数，肝动脉灌注和肝门静脉灌注（<0.05），明显低于对照组的0.05％。 CT灌注参数与MVD之间的相关性比II型或III型的更高。 结论：CT灌注成像对肿瘤的边缘可能有助于揭示组织病理学特征，并间接影响HCC的血管生成变化。

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  • 来源
    《国际肝胆胰疾病杂志（英文版）》 |2014年第006期|612-617|共6页
  • 作者

    Rong-Jie Bai; Jin-Ping Li; Shao-Hua Ren; Hui-Jie Jiang; Xin-Ding Liu; Zai-Sheng Ling; Qi Huang; Guang-Long Feng;

  • 作者单位

    Department of Radiology, Beijing Jishuitan Hospital, the Fourth Clinical Medical College of Peking University, Beijing 100035, China(Bai RJ);

    Department of Radiology, Second Afifliated Hospital, Harbin Medical University, Harbin 150086, China(Li JP, Jiang HJ, Liu XD, Ling ZS and Feng GL);

    Department of Radiology, the First Hospital of Harbin, Harbin 150010, China(Ren SH);

    and Department of Pathology, Harbin Medical University, Harbin 150086, China(Huang Q);

    Department of Radiology, Beijing Jishuitan Hospital, the Fourth Clinical Medical College of Peking University, Beijing 100035, China(Bai RJ);

    Department of Radiology, Second Afifliated Hospital, Harbin Medical University, Harbin 150086, China(Li JP, Jiang HJ, Liu XD, Ling ZS and Feng GL);

    Department of Radiology, the First Hospital of Harbin, Harbin 150010, China(Ren SH);

    and Department of Pathology, Harbin Medical University, Harbin 150086, China(Huang Q);

    Department of Radiology, Beijing Jishuitan Hospital, the Fourth Clinical Medical College of Peking University, Beijing 100035, China(Bai RJ);

    Department of Radiology, Second Afifliated Hospital, Harbin Medical University, Harbin 150086, China(Li JP, Jiang HJ, Liu XD, Ling ZS and Feng GL);

    Department of Radiology, the First Hospital of Harbin, Harbin 150010, China(Ren SH);

    and Department of Pathology, Harbin Medical University, Harbin 150086, China(Huang Q);

    Department of Radiology, Beijing Jishuitan Hospital, the Fourth Clinical Medical College of Peking University, Beijing 100035, China(Bai RJ);

    Department of Radiology, Second Afifliated Hospital, Harbin Medical University, Harbin 150086, China(Li JP, Jiang HJ, Liu XD, Ling ZS and Feng GL);

    Department of Radiology, the First Hospital of Harbin, Harbin 150010, China(Ren SH);

    and Department of Pathology, Harbin Medical University, Harbin 150086, China(Huang Q);

    Department of Radiology, Beijing Jishuitan Hospital, the Fourth Clinical Medical College of Peking University, Beijing 100035, China(Bai RJ);

    Department of Radiology, Second Afifliated Hospital, Harbin Medical University, Harbin 150086, China(Li JP, Jiang HJ, Liu XD, Ling ZS and Feng GL);

    Department of Radiology, the First Hospital of Harbin, Harbin 150010, China(Ren SH);

    and Department of Pathology, Harbin Medical University, Harbin 150086, China(Huang Q);

    Department of Radiology, Beijing Jishuitan Hospital, the Fourth Clinical Medical College of Peking University, Beijing 100035, China(Bai RJ);

    Department of Radiology, Second Afifliated Hospital, Harbin Medical University, Harbin 150086, China(Li JP, Jiang HJ, Liu XD, Ling ZS and Feng GL);

    Department of Radiology, the First Hospital of Harbin, Harbin 150010, China(Ren SH);

    and Department of Pathology, Harbin Medical University, Harbin 150086, China(Huang Q);

    Department of Radiology, Beijing Jishuitan Hospital, the Fourth Clinical Medical College of Peking University, Beijing 100035, China(Bai RJ);

    Department of Radiology, Second Afifliated Hospital, Harbin Medical University, Harbin 150086, China(Li JP, Jiang HJ, Liu XD, Ling ZS and Feng GL);

    Department of Radiology, the First Hospital of Harbin, Harbin 150010, China(Ren SH);

    and Department of Pathology, Harbin Medical University, Harbin 150086, China(Huang Q);

    Department of Radiology, Beijing Jishuitan Hospital, the Fourth Clinical Medical College of Peking University, Beijing 100035, China(Bai RJ);

    Department of Radiology, Second Afifliated Hospital, Harbin Medical University, Harbin 150086, China(Li JP, Jiang HJ, Liu XD, Ling ZS and Feng GL);

    Department of Radiology, the First Hospital of Harbin, Harbin 150010, China(Ren SH);

    and Department of Pathology, Harbin Medical University, Harbin 150086, China(Huang Q);

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  • 入库时间 2022-08-19 03:39:17
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