Familial chylomicronemia syndrome related chronic pancreatitis：a single-center study

摘要

BACKGROUND: Hypertriglyceridemia induces acute recurrent pancreatitis, but its role in the etiology of chronic pancreatitis (CP) is controversial. This study aimed to evaluate the clinical, laboratory and radiological ifndings of 7 patients with CP due to type 1 hyperlipidemia compared to CP patients with other or undeifned etiological factors. METHODS: We retrospectively analyzed the clinical, laboratory and radiological ifndings of 7 CP patients with type 1 hyper­ lipidemia compared to CP patients without hypertriglyceridemia. These 7 patients had multiple episodes of acute pancreatitis and had features of CP on abdominal CT, endoscopic retrograde cholangiopancreatography and/or endoscopic ultrasonography. RESULTS: All CP patients were classiifed into two groups: a group with type 1 hyperlipidemia (n=7) and a group with other etiologies (n=58). The mean triglyceride level was 2323±894 mg/dL in the ifrst group. Age at the diagnosis of CP in the ifrst group was signiifcantly younger than that in the second group (16.5±5.9 vs 48.3±13.5, P<0.001). The number of episodes of acute pancreatitis in the ifrst group was signiifcantly higher than that in the second group (15.0±6.8 vs 4.0±4.6, P=0.011). The number of splenic vein thrombosis in the ifrst group was signiifcantly higher than that in the second group (4/7 vs 9/58, P=0.025). Logistic regression analysis found that younger age was an independent predictor of CP due to hypertriglyceridemia (r=0.418, P=0.000). CONCLUSIONS: Type  1  hyperlipidemia  appears  to  be  an etiological factor even for a minority of patients with CP. It manifests at a younger age, and the course of the disease might be severe.