BACKGROUND: Pancreaticoduodenectomy with superior mesenteric/portal venous resection for pancreatic ductal ad-enocarcinoma (PDAC) is frequently performed with no added morbidity or mortality in case of tumor abutment to the su-perior mesenteric or portal vein so as to obtain a margin nega-tive resection. True histopathological portal vein invasion is found only in a small subset of such patients. The aim of this review aimed to discuss the signiifcance of histopathological venous invasion in PDAC. DATA SOURCES: For this review available data was searched from PubMed and analyzed. No randomized trials have been published on this topic. RESULTS: Existing data on prognostic factors in histopatho-logical venous invasion by PDAC are limited and recent stud-ies indicate worse survival in this subgroup of patients. In addition, venous invasion in PDAC has been associated with large tumors, involved lymph nodes, perineural invasion and R1 resection. The survival of patients with portal venous re-section but without histologic venous invasion is reportedly better than those with histopathological venous invasion;though conlficting studies do exist on the subject. Some stud-ies also relate the depth of venous invasion to prognosis after surgical resection of PDAC. CONCLUSIONS: Frank/‘histopathological’ invasion of supe-rior mesenteric/portal venous and R1 resection indicate a very poor survival. Such patients may be given the opportunity of beneift of neoadjuvant treatment.
展开▼
Hepato Pancreatico Biliary and Gastrointestinal Di-vision, Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi -221005 U.P., India;