Mechanism of hepatocytes differentiation and dedifferentiation in liver regeneration:Process and exploration

摘要

The liver has roles in many processes,including metabolism,synthesis,and biotransformation.It is unique among all visceral organs,as it even can regenerate after injury.A common research model of liver regeneration is the 2/3 partial hepatectomy(PHx)model in animals,like rodents,in which the left lateral,left medial,and right medial hepatic lobes are surgically removed[1].More-over,with the ability of hepatocyte hypertrophy and hyperplasia,within 7-10 days,the rest liver regenerates to its original size[2].Jo and colleagues[3]reported that splanchnic vasoactive agents could decrease portal vein pressure to facilitate the liver regenera-tion after 70%hepatectomy.However,liver regeneration and func-tion maintenance need adequate mass of future remnant liver.In-adequate mass of future remnant liver results in liver failure which loses the opportunity for the liver to regenerate and therefore,it is important to keep an adequate future remnant liver to avoid post-hepatectomy liver failure[4].