兔眼后囊膜混浊模型的建立

摘要

目的：总结兔眼后囊膜混浊模型建立过程中的成功经验及注意事项。　　方法：选择新西兰白兔10只，每只兔选取右眼进行超声乳化晶状体摘除术，对手术中的乳化功率、时间等参数进行统计。术后共随访3mo，观察术后并发症和后囊膜混浊的形成情况，按Odrich后囊膜混浊分级系统对术眼后囊膜混浊情况进行分级。　　结果：10只兔中有1只术中发生后囊膜破裂，1只于术后1wk死亡，其余8例术后1mo开始出现后囊膜混浊，术后2mo，后囊膜混浊的范围扩大并快速发展，术后3mo，形成致密纤维化层。术后3mo表现为致密的纤维化层和较厚的纤维化层，可见明显的后囊膜混浊。　　结论：利用兔眼透明晶状体行超声乳化手术可作为研究后囊膜混浊的理想动物模型，但要注意手术操作，防止并发症发生。%AIM: To summarize experience of posterior capsule opacification ( PCO) model in rabbit eye. METHODS: Ten New Zealand white rabbits whose right eyes had ultrasonic emulsification operation were randomly selected.Emulsifying power, time and other parameters were collected.The follow-up time was 3 months.The complications and the formation of PCO were recorded and classified according to Odrich PCO classification system. RESULTS: One case of 10 rabbits occurred posterior capsular rupture, 1 case died 1 week after surgery.PCO occurred in the remaining 8 rabbits 1 month after operation and range enlarged 2 months later. Dense fibrosis layer and thick fibrosis layer occurred 3 months later. CONCLU SION:An idealP CO animal model can be built in rabbit eye.We should pay attention to reduce the complications.