Immunomodulatory effects of Tim-3 and PD-1 on chronic hepatitis B virus infection

摘要

In patients with chronic hepatitis B virus(HBV) infection, the immune cells are dysfunctional, and the immune function cannot work normally. T-cell immunoglobulin mucin-3(Tim-3) and programmed death receptor-1(PD-1) are overexpressed on the surface of immune cells, such as cluster of differentiation(CD)4+, CD8+ T-lymphocytes, and natural killer(NK) cells. Many studies indicate that this phenomenon is closely related to the persistence, occurrence, development, and prognosis of HBV. Tim-3 and PD-1 may be used as new immune targets for the treatment of chronic hepatitis B.