壮阳促孕散对雌性肾阳虚大鼠垂体-性腺轴分泌激素的影响

摘要

试验研究了中药壮阳促孕散对雌性肾阳虚大鼠垂体-性腺轴分泌激素的影响,初步探讨其作用机制.用氢化可的松造雌性大鼠肾阳虚模型,造模21d,从试验第八天开始,中药治疗组灌胃中药壮阳促孕散,阳性对照组灌胃金匮肾气丸,连续给药14d.放射免疫法测定血清中雌二醇(E2)、孕酮(P)、黄体生成素(LH)和促卵泡激素(FSH).结果表明,模型对照组造模后大鼠出现明显的阳虚症状,体重下降,血清中E2、P下降,LH、FSH升高,给药后阳性对照组、中药治疗组大鼠体重增加,血清中E2、P升高,LH、FSH下降.中药壮阳促孕散可调节雌性肾阳虚大鼠血清中LH、FSH、E2和P的分泌,对生殖内分泌有促进作用.%To study the effects of traditional Chinese medicine ZCF on the hormones secretion of pituitary-gonad axis in kid-ney yang deficiency female rats and preliminarily discuss the action mechanism, the kidney-yang deficiency model of female rats was built by using hydrocortisone for 21 days. From the eighth day, Jinkuishenqi pill and traditional Chinese medicine ZCF was given to positive control group and treating group by gavage for 14 days, respectively. The contents of E2, P, LH and FSH in serum were determined by radioimmunoassay. After the model building, the control group presented obvious yang deficiency symptom. The weight of the rats decreased, the content of E2 and P in serum decreased but the contents of LH and FSH increased. After medication, the content of E2 and P in serum of the treating group increased; while the contents of LH and FSH decreased. It indicated that Chinese medicine ZCF could adjust the secretion of LH, FSH, E2 and P in serum of kidney-yang deficiency female rats, and had stimulative function on procreation endocrine.