Precise Functionalization of Remote C-H Bonds

摘要

Remote C-H bond functionalization of arenes with precise control is a recognized extraordinary challenge in organic synthesis.Recently.Yu and Houk el al.developed an elegant strategy to distinguish and functionalize remote Csp2-H bonds of(hetero)arenes within one-bond distance by the interplay of a remote directing template and a transient norbornene-type mediator.A wide range of medicinally important benzoazines are well compatible with this method The chemistry significantly expands the toolbox for site-selective functionalization of remote Co2-H bond of(hetero)arenes.This work has been published in Nature Chemistry in March,2020.