生长素响应因子(Auxin response factor,ARF)作为一类调控生长素响应基因表达的转录因子,是生长素研究的重要内容.它可与生长素响应基因启动子区域内的生长素响应元件结合,促进或抑制基因的表达.文章介绍了植物体内ARF家族的分子生物学近年来的研究进展,同时也讨论了ARF转录因子的结构、ARF基因的表达调控、ARF在植物生长发育及信号转导中的作用以及ARF对靶基因的调控机制等内容.植物ARF成员都有一定的同源性,大多含有4个结构域,在多种组织和器官中都有表达,其表达受到转录及转录后调控,并且在介导生长素与其它激素之间相互作用方面扮演重要角色.%An important aspect of studies on auxin is auxin response factors (ARFs), which activate or repress the auxin response genes by binding to auxin response elements (AuxREs) on their promoters. In this review, we focused on molecular biological advances of plant ARF families, and discussed ARF structures, regulation of ARF gene expression, the roles of ARFs in regulating the development of plants and in signal transduction and the mechanisms involved in the target gene regulation by ARFs. The phylogenetic relationships of ARFs in plants are close and most of them have 4 domains. ARFs are expressed in various tissues. Their expressions are regulated at both transcriptional and post-transcriptional levels. They play important roles in the interactions between auxin and other hormones.
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