目的 寻找一种具有显著类肉毒作用而淡化皱纹抗衰老的多肽,用于医疗美容领域和皮肤科药物领域.方法 采用多肽合成技术,通过对已经上市SYN-AKE化合物的结构式进行改造,合成一系列新的化合物.采用人肌细胞和来自小鼠胚胎脊髓神经元共培养模型模拟肌肉收缩,进行效果测试.结果 优选6种新合成多肽,H-(β-Ala)-Hyp-Dab-NH-苄基(C19H30N5O4)在1 min肌肉收缩次数变化率低于SYN-AKE(P<0.05).结论 H-(β-Ala)-Hyp-Dab-NH-苄基有望成为抗皱抗衰领域医疗美容新原料及皮肤科药物.%Objective To develop a new botox-like polypeptide with anti-wrinkle and anti-aging functions, which will be used in the field of cosmetics and dermatology. Methods A series of new peptide compounds were synthesized via modifying the structure of SYN-AKE by peptide synthesis technology. Simulating muscle contraction by using co-culture model of human muscle cells and mouse embryonic spinal cord neurons to test the effects. Results Six new synthetic peptides were selected. The results showed that the muscle contraction frequency was lowered by adding C19 H30 N5 O4 compound than adding SYN-AKE in 1 min(P<0.05). Conclusion C19H30N5O4 is expected to become a new cosmetic peptide raw material and dermatology drug in the field of anti-wrinkle and anti-aging.
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