枸橼酸坦度螺酮治疗广泛性焦虑症有效性和安全性的系统评价

摘要

Objective To systematically review the efficacy and safety of tandospirone in the treatment of generalized anx-iety disorder(GAD) and to provide evidence-based references for clinic. Methods Databases include PubMed,Embase,The Co-chrane Library,CBM,CNKI,VIP and Wanfang Data were electronically searched from the inception to November 2016,to collect randomized controlled trials(RCTs)about the tandospirone citrate in the treatment of generalized anxiety disorder.Meta-analysis was performed by RevMan5.3 software after data extraction and quality evaluation. Results A total of 5 RCTs involving 500 patients were included.The results of Meta-analysis showed no significant differences in the Hamilton Anxiety Scale(HAMA) score between experimental group and control group[MD=0.47,95%CI(-0.51,1.45),P=0.34];and there was no significant differences of total effective rate between experimental group and control group[OR=1.03,95%CI(0.64,1.67),P=0.90].The incidence of adverse reactions in experimental group was significantly lower than that of control group,the difference was statistically significant[OR=0. 65,95%CI(0.44,0.95),P=0.03]. Conclusion Tandospirone citrate,as a new type of non-BZDs of antianxiety drug,shows exact clinical curative effect in the treatment of generalized anxiety disorder with mild adverse reaction and good safety.%目的 系统评价枸橼酸坦度螺酮治疗广泛性焦虑症(GAD)的有效性和安全性,为临床提供循证参考.方法 计算机检索PubMed、EMbase、the Cochrane Library、中国生物医学文献数据库(CBM)、中国知网(CNKI)、维普中文期刊数据库(VIP)和万方数据库(Wanfang Data),搜集枸橼酸坦度螺酮治疗GAD的相关随机对照试验(RCT),时间为建库至2016年11月,提取资料并进行质量评估后,采用RevMan 5.3版软件进行Meta分析.结果 共纳入5个RCT,受试者500例.Meta分析结果显示,试验组汉密尔顿焦虑量表(HAMA)评分和对照组比较差异无统计学意义[MD=0.47, 95%CI(-0.51,1.45),P=0.34];试验组总有效率和对照组比较差异无统计学意义[OR=1.03,95%CI(0.64,1.67),P=0.90].试验组不良反应发生率明显低于对照组,差异有统计学意义 [OR=0.65,95%CI(0.44,0.95),P=0.03].结论枸橼酸坦度螺酮治疗GAD临床疗效确切,不良反应轻微,安全性较好.