树突细胞介导的自身免疫反应在动脉粥样硬化形成中的作用

摘要

目的：研究树突细胞介导的自生免疫反应对动脉粥样硬化（ AS）诱导作用。方法抽取59例冠心病患者作为观察组，取同期入院体检正常者50例作为对照组，采用三色分析测定患者血液标本中患者树突状细胞（ DC）及其亚型绝对数。结果观察组患者的DC、MDC、PDC的比例较对照组低，绝对值较对照组高，差异有统计学意义（ P＜0．05）。结论 DC能直接参与至动脉粥样硬化的形成中，在疾病的发生、发展中具有一定的促进作用。%ObjectiveTostudythedendriticcellsmediatedautoimmuneresponsesinatherosclerosis(AS).Methods 59patientswith coronary heart disease were selected as the object , and 50 healthy subjects were selected as control group .Patients were detected by DC analy-sis of blood samples of the patients to determine the tricolor (dendritic cells) and its subtypes in absolute numbers.Results In the observa-tion group, the ratios of DC, MDC and PDC were lower than the control group .And the absolute value was higher than that in control group , with statistically significant differences (P<0.05).Conclusion DC can be directly involved in the formation and atherosclerosis , and it has a certain role in the occurrence and development of diseases .