Objective: To investigate the applications of excimer laser in situ keratomileusis for asymmetric corneal near-sighted treatment,to provide a reference for clinical treatment. Method: Retrospective a-nalysis of 110 myopia patients (210 eyes) during May 2009 to May 2010,all patients were irregular corneal topography and received the first LASIK and divided into two groups, according to the spherical equivalent ＜ -6.00D was medium refractive group, 54 patients(105 eyes) ; ＞-6.00D of the rediopter group, 56 patients (105 eyes). All patients follow-up from 3 to 12 months,Compared the vision, refractive status and corneal asphericity coefficient (Q) change between the two groups. Result: Compared the two group during follow-up period, the postoperatives' visual acuity, refractive status and corneal asphericity coefficient ( Q) changes were better than preoperative, the difference was statistically significant (P ＜0.05). And the medium refractive group' s visual acuity, refractive status and corneal asphericity coefficient ( Q) changes were better than the rediopter group, the difference was statistically significant (P ＜0.05). Conclusion.- The effect of exci-mer laser in situ keratomileusis for asymmetric corneal near-sighted is significant, But the medium refractive group postoperative' s visual acuity, refractive status and corneal asphericity coefficient ( Q) changes were better than the rediopter group, is worth noting in clinical application.%目的:探讨准分子激光原位角膜磨镶术(LASIK)治疗非对称角膜近视眼的方法和应用效果,为临床治疗提供参考.方法:回顾性抽取分析本院于2009年5月至2010年5月的110例(210眼)角膜地形图为非对称或不规则且初次接受LASIK的近视患者分为两组,即按术前等效球镜分为＜ -6.00D的低中屈光组,54例(105眼)；＞-6.00D的重屈光度组,56例(105眼).随访3-12月,比较随访期间两组患者主要指标视力、屈光状态和角膜非球面系数(Q值)变化.结果:随访期间两组内相比,手术后的主要指标视力、屈光状态和角膜非球面系数(Q值)变化均优于手术前,差异有统计学意义(P＜0.05)；两组间相比,低中屈光度组患者的主要指标视力、屈光状态和角膜非球面系数(Q值)变化均优于重屈光度组,差异有统计学意义(P＜0.05).结论:应用准分子激光原位角膜磨镶术手术非对称角膜近视眼疗效显著,但术后低中屈光度患者的主要指标视力、屈光状态和角膜非球面系数(Q值)变化均明显优于重屈光度患者,此点在临床中值得注意.
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