波生坦治疗特发性肺动脉高压的临床研究

摘要

目的观察波生坦治疗特发性肺动脉高压的临床疗效及安全性.方法选择我院收治的15例特发性肺动脉高压患者，口服波生坦进行治疗，对比治疗前后患者的各项指标变化情况.结果治疗后，患者心功能得到了明显改善；6WMD、NT-proBNP、LVEDD、mPAP 等指标均较治疗前明显改善(P <0.05)；患者血常规及肝肾功能检查结果均无明显变化(P >0.05).结论波生坦是治疗特发性动脉高血压的安全有效的药物，值得向临床推荐.%　　Objective To observe the efficacy of Bosentan in idiopathic pulmonary hypertension (IPAH). Methods 15 patients with IPAH were treated with Bosentan, to compare the changes of indicator. Results After treatment, the patients’ cardiac function has been significantly improved, and other indicators had been improved significantly (P<0.05). Conclusion Bosentan is safe and effective in treatment of IPAH, and it is worthy of clinical recommendations.