普通肝素与低分子肝素治疗非大面积肺栓塞的临床疗效对比研究

摘要

目的：比较普通肝素与低分子肝素治疗非大面积肺栓塞的临床疗效。方法将49例非大面积肺栓塞患者随机划分为观察组26例（使用低分子肝素），对照组23例（使用普通肝素），比较两组的疗效及不良反应。结果总有效率：观察组96.15%，对照组91.30%（P＞0.05）；不良反应发生率：观察组3.85%，对照组8.70%（P＞0.05）；平均住院时间：观察组（9.4±1.2）d，对照组（15.3±2.9）d（P＜0.05）；平均费用：观察组（3642.6±592.1）元，对照组（5483.7±628.6）元（P＜0.05）。结论普通肝素与低分子肝素治疗非大面积肺栓塞的疗效、不良反应相似，但是运用低分子肝素患者其治疗时间更短、治疗费用更低，低分子肝素更值得临床推广运用。%Objective To compare the clinical curative of the ordinary heparin and low molecular heparin in effect non-massive PTE. Methods 49 patients with non-massive PTE were randomly divided into 26 cases of observation group(using low molecular heparin), 23 cases of control group(using the ordinary heparin), compared two groups of curative effect and adverse reactions. Result The total effective rate:observing group 96.15%, control group 96.15%(P>0.05);incidence of adverse reactions:observation group 3.85%, control group 8.70%(P>0.05);the average hospitalization time:observation group(9.4±1.2)day, control group(15.3±2.9)day(P<0.05).Average cost:observation group(3642.6±592.1)yuan, control group(5483.7±628.6) yuan(P<0.05). Conclusions Common heparin and low molecular heparin treatment of non-massive PTE curative effect and adverse reaction of similar, but the use of low molecular heparin in patients with the treatment time is shorter, lower cost of treatment, using low molecular heparin is more worthy of clinical promotion.