脑梗死患者超高倍显微镜下血小板聚集与阿司匹林抵抗关系的研究

摘要

Objective Directly view and analysis platelet cluster in patients with cerebral infarction under a ultra high power microscope, contrasting with clinical aspirin resistance, providing reference to predict clinical aspirin resistance. Methods Directly view peripheral blood platelet cluster of 150 cases of first-episode patients with cerebral infarction taking aspirin after 1 weeks with ACT-2000 ultra high power multimedia microscopy , tracking recurrent patients with cerebral infarction (Clinical resistance of aspirin) within 1 year after the first onset. Results The abnormal of platelet cluster were 85 cases(56.7%), recurrent brain infarction were 21 cases within one year, recurrent rate 24.7%;The normal of platelet cluster were 21 cases(43.3%), recurrent brain infarction were 5 cases (7.7%);there were significant difference in two groups (P<0.01). Conclusion The method is simple, intuitive and reliable. It may forecast clinical aspirin resistance.%目的：超高倍显微镜下直视分析脑梗死患者血小板聚集情况，并与发生临床阿司匹林抵抗的情况进行对比，为预测临床阿斯匹林抵抗提供参考。方法应用ACT-2000超高倍多媒体显微镜直接观察150例首发脑梗死患者服用阿斯匹林1周后外周血血小板聚集情况，跟踪患者首次起病后1年内是否复发脑梗死（临床阿斯匹林抵抗）。结果超高倍显微镜直视检查脑梗死患者的血小板聚集异常者85例，占56.7%，其中1年内脑梗死复发者21例，复发率24.7%；血小板聚集正常者65例，占43.3%，其中1年内脑梗死复发者5例，复发率7.7%；两组比较差异有统计学意义（P＜0.01）。结论服阿司匹林后超高倍显微镜下血小板聚集异常的脑梗死患者容易复发，该方法简便、直观、易行，可作为预测临床阿斯匹林抵抗的参考依据。