某院临床下呼吸道感染病原菌种类及耐药性的分析

摘要

Objective To understand and grasp our hospital in 2013 clinical lower respiratory infection pathogenic bacteria species and drug resistance, to guide clinical rational drug use.Methods The BD phoenix 100 automatic bacteria identification application database data in 2013 and drug susceptibility testing system WHONET5.5 retrospective statistical analysis of bacterial drug resistance monitoring software.Results Gram-negative bacteria 60.42%;Gram-positive bacteria 9.98%; Fungi was 29.60%. Gram-negative bacteria klebsiella pneumoniae in 31.01%, 13.62% E. coli, pseudomonas aeruginosa 7.83%; Gram positive bacterium staphylococcus aureus 54.39%, streptococcus pneumoniae 22.81%; Fungi white candida yeast 55.03%, and 31.95% tropical candida.Conclusions The lower respiratory tract infection is given priority to with gram-negative bacteria 60.42%, klebsiella pneumoniae detection rate is highest, its to amoxicillin/clavulanic acid, piperacillin, ampicillin/shu ba present high drug resistance. E. coli resistance, resistance to an average of 33.68%. Gram-positive bacteria infection is given priority to with staphylococcus aureus, sugar peptide, pbo alkane ketone is still the most effective treatment of gram-positive bacteria infection. Bacteria merged fungi double infection should not be ignored, to strengthen the resistant monitoring and to guide clinical rational drug use.%目的：了解并掌握2013年我院临床下呼吸道感染病原菌种类及耐药性，指导临床合理用药。方法美国BD phoenix 100全自动细菌鉴定药敏检测系统数据库2013年数据并应用WHONET5.5细菌耐药监测软件进行回顾性统计分析。结果革兰阴性菌60.42%；革兰阳性菌9.98%；真菌29.60%。革兰阴性菌中肺炎克雷伯菌31.01%，大肠埃希菌13.62%，铜绿假单胞菌7.83%；革兰阳性菌中金黄色葡萄球菌54.39%，肺炎链球菌22.81%；真菌中白假丝酵母菌55.03%，热带假丝酵母菌31.95%。结论下呼吸道感染以革兰阴性菌为主60.42%，肺炎克雷伯菌检出率最高，其对阿莫西林/克拉维酸、哌拉西林、氨苄西林/舒巴坦呈现较高耐药。大肠埃希菌耐药严重，平均耐药率33.68%。革兰阳性菌感染以金黄色葡萄球菌为主，糖肽类、恶唑烷酮类仍是治疗革兰阳性菌感染最有效的药物。细菌合并真菌的二重感染不容忽视，加强耐药监测，指导临床合理用药。