犬吸入性肺损伤血流动力学改变

摘要

目的：本研究拟成功复制犬热蒸汽吸入性肺损伤模型，并探讨急性吸入性肺损伤早期重要生命体征的变化情况，以及与心肺功能密切相关的连续心输出量（CCO）、心排指数（CI）、每搏量变异度（SVV）等核心血流动力学指标的变化规律。方法建立犬热蒸汽吸入性肺损伤模型，动物随机分为4组，对照组（未予以致伤）。肺水肿组：根据肺损伤肺水肿后观察时间的不同分为B 1组：1 h；B2组：2 h及B3组：4 h。试验中监测ABP、SVV、CO等血流动力学指标。结果犬蒸汽吸入性肺损伤致伤后，早期即发生循环动力学的变化，以致伤后30min至1 h最为明显，ABP、HR、CO持续下降，SVV较前升高。结论犬蒸汽吸入性肺损伤致伤后，早期即发生循环动力学的变化，造成动物氧合及代谢障碍，并可以迅速导致肺水肿，以致伤后30min至1 h最为明显。%Objective To establish a model of acute inhalation injury in dogs,and to investigate the changes of vi-tal signs in the early stage of acute inhalation injury and the correlation between cardiac output (CCO),cardiac output index CI),stroke volume variability (SVV)and other core hemodynamic variables. Methods The animal models of inhaled lung injury were established. The animals were randomly divided into four groups:control group (no injury);Lung edema group:according to the observation time of lung injury after lung injury,they were divided into B1 group:1 h;B2 group:2 h and B3 group:4 h. The hemodynamic indexes such as ABP,SVV and CO were monitored. Results The changes of circulatory ki-netics occurred in the early stage of the injury after aspiration of canine vapor inhalation,which was most obvious in 30 mi-nutes to 1 hour after injury. The levels of ABP,HR,CO were decreased and SVV was increased. Conclusion Inhalation of lung injury in dogs after inhalation,early changes in the occurrence of circulatory dynamics occured,resulting in animal oxy-genation and metabolic disorders,and these can quickly lead to pulmonary edema,so that 30 minutes to 1 hour after injury, hemodynamic chcnge were the most obvious.