State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 ChinaUniversity of the Chinese Academy of Sciences Beijing 100049 ChinaInstitute for Stem Cell and Regeneration Chinese Academy of Sciences Beijing 100101 China;
Beijing Advanced Innovation C enter for Food Nutrition and Human Health China Agricultural University Beijing 100193 ChinaState Key L aboratory of Agrobiotechnology College of Biological Sciences China Agricultural University Beijing 100193 China;
Departm ent of Human Genetics University of Utah School of Medicine Salt Lake City UT 84112 USA;
Whitehead Institute for Biomedical Research Cambridge MA 02142 USADepartm ent of Biology Massachusetts Institute of Technology Cambridge MA 02142 USA;
animal model; CRISPR; genome editing; TALEN; ZFN;