Reprogramming of the pig primordial germ cells into pluripotent stem cells: a brief review

摘要

Primordial germ cells (PGCs) are regarded as unipotent cells that can produce only either spermatogonia or oocytes.However,PGCs can be converted into the pluripotent state by first dedifferentiation to embryonic germ cells and then by reprogramming to induce them to become pluripotent stem cells (iPSCs).These two stages can be completely implemented with mouse cells.However,authentic porcine iPSCs have not been established.Here,we discuss recent advances in the stem cell field for obtaining iPSCs from PGCs.This knowledge will provide some clues which will contribute to the regulation of reprogramming to pluripotency in farm species.