Purpose: To evaluate the effect of intracameral anesthesia on the anterior segment ofrabbit eyes using chinese-made lidocaine.Method: The study comprised eight eyes of four white rabbits which were divided intothree groups according to the concentration of the lidocaine given. They are 0.5%, 1%,2% lidocaine groups and balanced salt solution(BSS)control group. Each groupcontained two eyes.After 0.5 ml of the anesthetic agent was injected into the anteriorchamber and retainedthere for ten minutes, the rabbits were executed and the eye balls wereenucleated. Pathological examinations of the anterior segment, including cornea, iris andcilliary body, were carried out immediately.Result:The pathological study revealed no abnormal findings in lidocaine 0. 5% and 1%groups compared with the control group, where as in the lidocaine 2% group, muchabnormal pathological change was found, including the shrinkage of corneal endothelium,stroma edema of iris and cilliary body.Conclusion: Using intracameral anesthesia of high concentration of chinese-made lidocainewould run a risk of damaging the anterior segment of rabbit eye. But at the low concentrationusually usedin cataract surgery, no adverse effect was found.
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