不同类型恶性肿瘤患者血清同型半胱氨酸水平的比较

摘要

Objective To compare the serum homocysteine (HCY) levels in patients with five types of malignant tumors. Methods A total of 153 cases of malignant tumors,including 31 with lung cancer,37 with colorectal cancer,33 with cervical can-cer,27 with primary hepatic carcinoma and 25 with breast cancer admitted into Jiangxi cancer hospital from October 2015 to Jan-uary 2016,were selected as the objects of study. The serum HCY levels were measured by circulating enzymeassay. Results ⑴There were significant differences in the serum HCY level among group A1,B1,C1,D1 and E1(P<0.05). The serum HCY levels in group A1 were significantly higher than that in group C1,D1 and E1,respectively (P<0.05),while statistical difference in serum HCY level were not present between any other 2 groups (P>0.05). There were no significant differences in serum HCY level among group A2,B2,C2,D2 and E2 (P>0.05). ⑵There were no significant differences in serum HCY level among group A3,B3,C3,D3 and E3 (P>0.05),and no statistical differences in serum HCY level among group A4,B4 and C4 (P>0.05). Conclusion There are differences in some degree in serum HCY level among 5 different types of malignant tumor,and the patients with primary hepatic carcinoma are more susceptible to hyperhomocysteine.%目的：比较不同类型恶性肿瘤患者的血清同型半胱氨酸（HCY）水平。方法选取江西省肿瘤医院2015年10月-2016年1月收治的153例恶性肿瘤患者作为研究对象，其中原发性肝癌27例、结直肠癌37例、肺癌31例、子宫颈癌33例、乳腺癌25例。采用循环酶法测定所有研究对象的血清HCY。结果⑴A1、B1、C1、D1、E1组之间血清HCY差异有统计学意义（P＜0.05），A1组之间血清HCY显著高于C1组、D1组、E1组（P＜0.05），血清HCY在其余各组间两两比较差异均无统计学意义（P＞0.05）。A2、B2、C2、D2、E2组之间血清HCY差异无统计学意义（P＞0.05）。⑵A3、B3、C3、D3、E3组之间血清HCY差异无统计学意义（P＞0.05），A4、B4、C4组之间血清HCY差异无统计学意义（P＞0.05）。结论不同类型恶性肿瘤患者血清HCY水平存在一定的区别，原发性肝癌患者较易发生高HCY血症。