首页> 中文期刊> 《工程(英文)》 >SARS-CoV-2侵入因子——ACE2和TMPRSS2在围着床期胚胎和母胎界面存在表达

SARS-CoV-2侵入因子——ACE2和TMPRSS2在围着床期胚胎和母胎界面存在表达

             

摘要

在全球肆虐的严重急性呼吸综合征冠状病毒2(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)导致了大量人群感染,血管紧张素转化酶2(angiotensin-converting enzyme 2,ACE2)是SARS-CoV和SARS-CoV-2的受体蛋白.然而是否存在SARS-CoV-2的垂直传播仍颇有争议.为了探讨SARS-CoV-2垂直传播的潜在风险,我们利用已发表的单细胞转录组数据观察了围着床期胚胎和母胎界面上ACE2和TMPRSS2(编码跨膜丝氨酸蛋白酶2)的转录表达情况.结果显示,ACE2和TMPRSS2在第6天(D6)围着床期胚胎的滋养外胚层(trophectoderm,TE)细胞、妊娠第8周的合胞滋养层(syncytiotrophoblast at 8 weeks of gestation,STB_8W)细胞以及妊娠第24周的绒毛外滋养层(extravillous trophoblasts at 24 weeks of gestation,EVT_24W)细胞中均存在明显的共表达现象,表明这些细胞类群可能易被SARS-CoV-2感染.在这三个细胞类群中,ACE2阳性表达细胞相对于阴性细胞在自噬和免疫相关过程中存在差异.尽管ACE2的表达水平在围着床期胚胎中没有表现出性别偏差,但是其在D6 TE、第6天围着床期胚胎的原始内胚层(D6 primitive endoderm,D6 PE)细胞以及ACE2阳性表达的STB细胞中存在明显的性别差异.这表明围着床期发育第6天以及妊娠期胚胎对SARS-CoV-2的易感性可能存在性别差异.我们的结果揭示了胚胎移植过程中,围着床期以及妊娠期胚胎面临着SARS-CoV-2的潜在感染风险.

著录项

  • 来源
    《工程(英文)》 |2020年第010期|1162-1169中插119-中插128|共18页
  • 作者单位

    Center for Reproductive Medicine Department of Obstetrics and Gynecology Peking University Third Hospital Beijing 100191 China;

    Key Laboratory of Assisted Reproduction (Peking University) Ministry of Education Beijing 100191 China;

    Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Peking University Third Hospital Beijing 100191 China;

    Academy for Advanced Interdisciplinary Studies Peking University Beijing 100871 China;

    Peking–Tsinghua Center for Life Sciences Peking University Beijing 100871 China;

    Center for Reproductive Medicine Department of Obstetrics and Gynecology Peking University Third Hospital Beijing 100191 China;

    Key Laboratory of Assisted Reproduction (Peking University) Ministry of Education Beijing 100191 China;

    Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Peking University Third Hospital Beijing 100191 China;

    Academy for Advanced Interdisciplinary Studies Peking University Beijing 100871 China;

    National Clinical Research Center for Obstetrics and Gynecology Beijing 100191 China;

    Beijing Advanced Innovation Center for Genomics Beijing 100871 China;

    Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest Beijing 100191 China;

    Center for Reproductive Medicine Department of Obstetrics and Gynecology Peking University Third Hospital Beijing 100191 China;

    Key Laboratory of Assisted Reproduction (Peking University) Ministry of Education Beijing 100191 China;

    Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Peking University Third Hospital Beijing 100191 China;

    Center for Reproductive Medicine Department of Obstetrics and Gynecology Peking University Third Hospital Beijing 100191 China;

    Key Laboratory of Assisted Reproduction (Peking University) Ministry of Education Beijing 100191 China;

    Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Peking University Third Hospital Beijing 100191 China;

    Academy for Advanced Interdisciplinary Studies Peking University Beijing 100871 China;

    Peking–Tsinghua Center for Life Sciences Peking University Beijing 100871 China;

    Center for Reproductive Medicine Department of Obstetrics and Gynecology Peking University Third Hospital Beijing 100191 China;

    Key Laboratory of Assisted Reproduction (Peking University) Ministry of Education Beijing 100191 China;

    Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Peking University Third Hospital Beijing 100191 China;

    Academy for Advanced Interdisciplinary Studies Peking University Beijing 100871 China;

    Peking–Tsinghua Center for Life Sciences Peking University Beijing 100871 China;

    Center for Reproductive Medicine Department of Obstetrics and Gynecology Peking University Third Hospital Beijing 100191 China;

    Key Laboratory of Assisted Reproduction (Peking University) Ministry of Education Beijing 100191 China;

    Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Peking University Third Hospital Beijing 100191 China;

    Academy for Advanced Interdisciplinary Studies Peking University Beijing 100871 China;

    Peking–Tsinghua Center for Life Sciences Peking University Beijing 100871 China;

    Center for Reproductive Medicine Department of Obstetrics and Gynecology Peking University Third Hospital Beijing 100191 China;

    Key Laboratory of Assisted Reproduction (Peking University) Ministry of Education Beijing 100191 China;

    Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Peking University Third Hospital Beijing 100191 China;

    National Clinical Research Center for Obstetrics and Gynecology Beijing 100191 China;

    Beijing Advanced Innovation Center for Genomics Beijing 100871 China;

    Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest Beijing 100191 China;

    Center for Reproductive Medicine Department of Obstetrics and Gynecology Peking University Third Hospital Beijing 100191 China;

    Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Peking University Third Hospital Beijing 100191 China;

    National Clinical Research Center for Obstetrics and Gynecology Beijing 100191 China;

    Center for Reproductive Medicine Department of Obstetrics and Gynecology Peking University Third Hospital Beijing 100191 China;

    Key Laboratory of Assisted Reproduction (Peking University) Ministry of Education Beijing 100191 China;

    Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Peking University Third Hospital Beijing 100191 China;

    Academy for Advanced Interdisciplinary Studies Peking University Beijing 100871 China;

    Peking–Tsinghua Center for Life Sciences Peking University Beijing 100871 China;

    Center for Reproductive Medicine Department of Obstetrics and Gynecology Peking University Third Hospital Beijing 100191 China;

    Key Laboratory of Assisted Reproduction (Peking University) Ministry of Education Beijing 100191 China;

    Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Peking University Third Hospital Beijing 100191 China;

    Academy for Advanced Interdisciplinary Studies Peking University Beijing 100871 China;

    Peking–Tsinghua Center for Life Sciences Peking University Beijing 100871 China;

    National Clinical Research Center for Obstetrics and Gynecology Beijing 100191 China;

    Beijing Advanced Innovation Center for Genomics Beijing 100871 China;

    Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest Beijing 100191 China;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类
  • 关键词

    SARS-CoV-2; ACE2垂直传播胎盘围着床期;

    机译:SARS-CoV-2;ACE2垂直传播胎盘围着床期;
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