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Regenerative Engineering for Knee Osteoarthritis Treatment: Biomaterials and Cell-Based Technologies

         

摘要

膝关节骨性关节炎(OA)是世界上最常见的关节炎,其发病率逐年上升。不断上涨的治疗费用给患者带来了经济负担。膝关节OA治疗的两个早期干预目标是减轻膝关节的疼痛和关节软骨的损害。目前用于治疗膝关节OA的方法虽取得了一定疗效,但仍没有一种方法可达到全膝关节置换术(TKA)的治疗效果。TKA主要应用于治疗末期膝关节OA,其缺点是有手术侵入性和手术费用昂贵。因而,应该重视创新性的再生技术,以推迟甚至消除患者对TKA的需求。一些基于生物材料和细胞的疗法目前正处于发展阶段,并已在临床前和临床研究方面取得了初步进展。单独或联合应用先进的生物材料和干细胞治疗膝关节OA可减轻疼痛,使损害的关节软骨再生。在此综述中,我们讨论了膝关节OA疼痛和软骨损害的发病机制,并探讨了该病的最新治疗策略及其局限性。

著录项

  • 来源
    《工程(英文)》 |2017年第1期|16-27|共12页
  • 作者单位

    Institute for Regenerative Engineering;

    University of Connecticut Health Center;

    Farrnington;

    CT 06030;

    USA;

    Raymond and Beverly Sackler Center for Biomedical;

    Biological;

    Physical and Engineering Sciences;

    University of Connecticut Health Center;

    Farmington;

    CT 06030;

    USA;

    Department of Orthopaedic Surgery;

    University of Connecticut Health Center;

    Farmington;

    CT 06030;

    USA;

    Department of Biomedical Engineering;

    School of Engineering;

    University of Connecticut;

    Storrs;

    CT 06269;

    USA;

    Department of Materials Science and Engineering;

    School of Engineering;

    University of Connecticut;

    Storrs;

    CT 06269;

    USA;

    Institute of Materials Science;

    University of Connecticut;

    Storrs;

    CT 06269;

    USA;

    Department of Craniofacial Sciences;

    School of Dental Medicine;

    University of Connecticut Health Center;

    Farmington;

    CF 06030;

    USA;

    Department of Chemical and Biomolecular Engineering;

    School of Engineering;

    University of Connecticut;

    Storrs;

    CT 06269;

    USA;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 自然科学总论;
  • 关键词

    膝关节骨性关节炎; 骨关节炎疼痛; 间充质干细胞; 生物材料; 再生工程;

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