Objective: Clozapine is regarded as the most effective drug for treatment of schizophrenia but has complex adverse effects associated with hyperglycemia and diabetes mellitus. Method: We report that clozapine was very effective to treat positive, negative, and cognitive symptoms and well tolerated to a treatment-resistant schizophrenia patient with severe type 2 diabetes mellitus (DM) under cautious blood-sugar monitoring. Results: Clozapine itself and discontinuation of other psychotropic and anticholinergic agents after switching may improve cognitive function and adherence to the treatment regimens for schizophrenia and DM. Conclusion: Clozapine can be administered to treatment-resistant schizophrenia patients even with severe DM with caution.
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机译:Diabetes mellitus:fatores de risco emuumastituiçãodeensinonaáreaodaaúdeLosfactores de riesgo para los Diabetes mellitus tipo 2deinstitucióndeenseñanzaType-2 Diabetes mellitus:一所学校在健康领域的风险因素