Fertaric acid amends bisphenol A-induced toxicity,DNA breakdown,and histopathological changes in the liver,kidney,and testis

摘要

BACKGROUND Bisphenol A(BPA)is present in many plastic products and food packaging.On the other hand,fertaric acid(FA)is a hydroxycinnamic acid.AIM To investigate the effect of FA on BPA-related liver,kidney,and testis toxicity,DNA breakdown,and histopathology in male rats.METHODS Thirty male albino rats were divided into five equal groups(6 rats/group):Control,paraffin oil,FA-,BPA-,and FA+BPA-treated groups.The control and paraffin oil groups were administered orally with 1 mL distilled water and 1 mL paraffin oil,respectively.The FA-,BPA-,and FA+BPA-treated groups were administered orally with FA(45 mg/kg,bw)dissolved in 1 mL distilled water,BPA(4 mg/kg,bw)dissolved in 1 mL paraffin oil,and FA(45 mg/kg,bw)followed by BPA(4 mg/kg,bw),respectively.All these treatments were given once a day for 6 wk.RESULTS BPA induced a significant decrease in serum alkaline phosphatase,acid phosphatase,sodium,potassium and chloride,testosterone,dehydroepiandrosterone sulfate,glucose-6-phosphate dehydrogenase,3β-hydroxysteroid dehydrogenase,and testis protein levels but a highly significant increase in serum aspartate aminotransferase,alanine aminotransferase,γ-glutamyl transpeptidase,lactate dehydrogenase,bilirubin,urea,creatinine,uric acid,luteinizing hormone,follicle stimulating hormone,sex hormone binding globulin,blood urea nitrogen,and testis cholesterol levels.Also,FA inhibited the degradation of liver,kidney,and testis DNA content.Oral administration of FA to BPA-treated rats restored all the above parameters to normal levels.CONCLUSION FA ameliorates BPA-induced liver,kidney,and testis toxicity,DNA breakdown,and histopathological changes.