Histone acetylation and its role in embryonic stem cell differentiation

摘要

The understanding of mechanisms leading to cellular differentiation is the main aim of numerous studies.Accessibility of DNA to transcription factors depends on local chromatin structure and chromatin compaction inhibits gene transcription.Histone acetylation correlates with an open chromatin structure and increased gene expression.Gene transcription levels are changed in early embryonic stem cells differentiation in a tissuespecific manner and epigenetic marks are modified,including increased global acetylation levels.Manipulation of histone deacetylases activity might be an interesting tool to generate populations of specific cell types for transplantation purposes.Thus,this review aims to show recent findings on histone acetylation,a post translational modif ication and its manipulation in embryonic stem cells differentiation.