Study on Anti-tumor Mechanism of Poria cocos Based on Network Pharmacology

摘要

Background:This paper investigates the anti-tumor mechanism of action of Poria cocos on the basis of network pharmacology.Method:In this paper,we screen the potential active ingredients of Poria cocos by TCMSP and obtain their corresponding targets with SwissTargetPrediction.The GeneCards and OMIM databases are used to screen the relevant pathogenic candidate targets in various tumor disease processes.Furthermore,we obtain Poria cocos-tumor common targets by taking the intersection of Poria cocos potential targets and candidate target groups.Subsequently,the protein-protein interaction network(PPI)of common target genes is mapped based on the STRING database,and the"drug-active component-target gene-disease"network is constructed with the help of Cytoscape3.7.2.Therefore,the core target genes are obtained.Finally,GO and pathway enrichment analysis of the core target genes are performed by Metascape and DAVID.Results:38 common targets and 7 core genes(ESR1,MAPK3,MAPK8,MTOR,PIK3CA,JAK2,and IL6)in Poria cocos-tumors are found.They play an anti-tumor role by regulating various classical pathways such as PI3K-Akt signaling pathway,mTOR signaling pathway,Prolactin signaling pathway,ErbB signaling pathway,Choline metabolism in cancer.Conclusion:The research reveals the effective anti-tumor function of Poria as a multi-component,multi-target and multi-pathway herbal medicine.