Exploiting the inherent invasive property to treat glioblastoma multiforme

摘要

Glioblastoma multiforme(GBM)is the most malignant brain tumor with high infiltration.The routine surgical resection followed by radiation and chemotherapy only provides patients with a survival period ranging 12–15months.Here,I propose that the high invasiveness property of the GBM cells be exploited to treat this deadly disease.That is,instead of inhibiting the dissemination of GBM cells,we should take advantage of the high mobility of the disseminated GBM cells and directionally induce these cells to return to the center of surgical resection cavity of the primary neoplasm and subsequently kill them.This idea may provide a new promise to defeat this deadly disease.