加替沙星中主要杂质P-去甲加替沙星的分离、合成与结构鉴定

摘要

AIM:To identify the main impurity of gatifloxacin.METHOD:P-demethylgatifloxacin was synthesized in four steps from ethyl 2-(3-methoxy-2,4,5-trifluorobenzoyl)-3-(cyclopropylamino) acrylate through cyclization,chelation,N-piperazination and hydrolysis,and identified by LC/MS,UV, 1 HNMR , 13 CNMR ,MS.RESULT:the main impurity of gatifloxacin was P-demethylgatifloxacin.