The current corona-2 pandemic has stimulated wide research for hydroxychloroquine(Quine)therapy and lately,prophylaxis.To optimize prophylaxis proper methods of use are explained.The focus is on tools of assessment and robust comparison;defining infection objectively;loading and maintenance dose designing based on pharmaco-viro-kinetics;confirming Quine threshold-levels and its sufficiency;and Quine side-effects vigilance/amelioration.Attention to statistics to study valid endpoints of goals in appropriately-sized population is essential.Mass interactive quine dose auto designer software is built to simplify,optimize and help collaboration of complex Quine dosing system.A similar chloroquine software can be built.
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