Age-specific reference ranges of prostatespecific antigen in the elderly of Amirkola: A population-based study

摘要

Objective:To determine the age-specific reference ranges of prostate-specific an­tigen(PSA)in the older men in the city of Amirkola.Methods:This cross-sectional study is a part of Amirkola Health and Ageing Project(AHAP)which has been conducted as a cohort study since 2011 in Amirkola,a city in northern Iran.The demographic information of all men aged 60 and older were collected through question­naires and interviews and the PSA measurements were performed using ELISA and Diametra kit.The acquired data were analyzed afterwards.Results:A number of 837 elderly men with a mean age of 69.99±7.72 years participated in this study.The serum PSA level(95th percentile)was determined to be 0.9(0-4.89)ng/mL in the age group of 60-64 years,1.1(0-4.88)ng/mL in the age group of 65-69 years,0.93(0-9.01)ng/mL in the age group of 70-74 years,1.3(0-7.95)ng/mL in the age group of 75-79 years,1.9(0-11.98 ng/mL)in the age group of 80-84 years,and 1.45(0-33.17)ng/mL in the 85 and older group.The serum PSA level was significantly correlated with age(p=0.000).Conclusion:This study indicated that there is a direct correlation between the age and serum PSA levels.The use of age-specific reference range could guide clinicians on the incidence of prostate cancer in this population and perhaps reduce the number of unnecessary tests in this population group.