Translating laboratory anti-aging biotechnology into applied clinical practice:Problems and obstacles

摘要

Although the use of biomedical technologies against ageing(rejuvenation biotechnologies) is considered by many as an effective way of controlling all age-related degeneration,in reality this belief cannot be justified. The human body is notoriously resistant to external perturbations and can respond in unpredictable or undesirable ways. Basic concepts of science,evolution and disease must also be considered. In this paper,I discuss some relevant problems associated with the application of any putative rejuvenation biotechnologies such as stem cell therapies,genetic engineering,tissue manipulation,as well as pharmacological approaches. I conclude that these and other biotechnologies will not be applicable to humans in the community. This is due to a wide spectrum of problems and obstacles,such as unpredictable therapeutic results,unrealistic expectations,lack of infrastructure,cellular network disruption,and many more. Even if some such technologies are developed,the totality of the problems,issues and side effects will prove an insurmountable final hurdle,rendering the development of such therapies,essentially and practically useless.