Daphmacrodins A and B, alkaloids from Daphniphyllum macropodum

摘要

Two new daphnicyclidin-type Daphniphyllum alkaloids,daphmacrodins A and B(1 and 2)were isolated from the leaves and stems of Daphniphyllum macropodum.Their structures were elucidated by extensive spectroscopic techniques,including 2D NMR spectroscopy and mass spectrometry.The relative configuration of 1 was further confirmed by a single-crystal X-ray diffraction analysis.Their cytotoxic activities against five human cancer cell lines,pesticidal activities against brine shrimp(Artemia salina),and antibacterial activities against five standard bacterial and fungal strains were evaluated.The structure of 1 was successfully transformed to 2 by a chemical method.