Effects of tap water, electrolyte solution, and spontaneous and furosemide-stimulated urinary excretion on thirst

摘要

AIM: To contrast the effects of various modifications of body fluid volumes on thirst as reported by healthy volunteers. METHODS: Ten male volunteers aged between 19 and 37 years(mean 22 years) underwent four experiments each, which comprised infusion of 400-800 m L of acetated Ringer's solution and intake of 600 m L of tap water. Half of the experiments were preceded by volume depletion(median 1.7 L) with furosemide. A visual analogue scale(0-100 mm) was used to assess perceived thirst during each experiment. RESULTS: Volume depletion(P 60 mm) while the others reported no change.