The appropriate use of animal models is one of the most important steps for a successful translational research project.For scientists working in basic biomaterials research and development,the problem is the uncertainty in selecting the most suitable models for a particular research question.Because of the complexity of translational research,the choice of animal model must be a thorough and clearly-defined process in order to provide relevant,reliable and translatable scientific data,ensure the most beneficial use of the animals,and to be accepted by peers.As stated by Bernard Rollin,1“The most brilliant design,the most elegant procedures,the purest reagents,along with investigator talent,public money,and animal life are all wasted if the choice of animal is incorrect.”To design a successful animal experiment,many questions need to be addressed.
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