MECHANISMS OF CONTRALATERAL HEAT HYPERALGESIA INDUCED BY SUBCUTANEOUS INTRAPLANTAR BEE VENOM INJECTION IN RATS

摘要

Aim: It has been found that subcutaneous intraplantar injection of bee venom (BV) unilaterally could produce contralateral heat hyperalgesia as well as primary heat and mechanical hyperalgesia in adult rats. The aim of the present study is to investigate: (1) whether contralateral heat hyperalgesia is a consequence of central sensitization, and whether, if it is the case, establishment of central sensitization is dependent upon a