Mapping It out: A Novel Signaling Pathway Linking Aβ-PrPsupc/sup-Fyn Complex to Cognitive Impairment in Alzheimer’s Disease

摘要

Understanding the signaling cascade that leads to the rapid memory and cognitive breakdown in Alzheimer’s disease is the key to finding a potential treatment method for the disease. Recently, Larson et al. connect the roles of major proteins implicated in the disease progression and propose targeting of cellular prion protein (PrPc) as a way of someday rescuing synaptic plasticity in humans with Alzheimer’s, as it has been done on mice.