Experimental studies of relationship between phospholipid level and Yangxueqingnao particles in transient cerebral ischemia attack

摘要

AIM:To investigate the effect of transie nt ischemia attack(TIA)on phospho-lipid level and the effect of traditi onal Chinese herb -Yangxueqingnao p ar-ticles.METHODS:To establish the animal model of TIA i n mice by injecting Peroxide through caudal vein,and th en feed the mice with Yangxueqingnao particles in different dose.After e voking 4times of TIA and cut off the head the other day,then measure the level of lysophosphatidic acid(LPA),general phospholipid in blood plasma and bra in tissue.RESULTS:Score of the group without treatment was 1.0±0.8,while that of group administered with Yangxueqingnao particles(2g /kg)was 0.5±0.4(P<0.05)LPA level of TIA mice were 6.1±0.4and 2.1±1.3and increased significantly com-pared with that of the control.This c hanges can be reversed by treatment as can be seen the result 4.9±1.6.general phospholipid level of TIA mice in brain tissue decreased significantly com pared with that of the control as the r esult:(2.3±1.1)and(6.6±2.8)μmol /g,respectively.After treatme nt,general phopholipid level can reach(4.3±2.0)μmol /g.CONCLUSION:LPAand general phospholipid levels in bloo d plasma and brain tissue are abnorma l in experimental TIA mice,but can be rev ersed by Yangxueqingnao particles a nd it can be used in treatment.