GENE EXPRESSION IN NEUROPATHIC PAIN MODELS

摘要

Fluctuations in gene expression that reflect changes in the functional demands on individual neurons are an everyday occurrence. With sustained peripheral inflammation, however, prolonged C-fiber activation alters the pattern of gene transcription in dorsal root ganglion (DRG) cells and dorsal horn neurons. Following peripheral nerve injury changes in neuronal excitability and mRNA levels in sensory neurons offer s substrate for chronic pain. Several mechanisms that contribute to increased excitability in DRG have recently been discovered.