Cyclooxygenase-2 and Decidual Immune Cells

摘要

Cyclooxygenase?2 (COX?2) is a rate?limiting enzyme in arachidonic acid (AA) metabolism. COX?2 and its products (prostanoids) serve versatile biological functions during pregnancy. Numerous evidences demonstrate special reprogramming of COX?2?catalyzingAAmetabolism in decidual immune cells (DICs), particularly in decidual macrophages, corresponding to special gestational phases. This review summarizes the reprogramming of COX?2?catalyzing AA metabolism in DICs as well as the immunoregulation of diverse COX?2?generating prostanoids in DICs during the different phases of gestation.